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SourcesThe studies behind what we say about wound care

Where this comes from.

5 claims · 8 studies.

C9-1
Moist wound healing accelerates re-epithelialization by approximately 50% vs air-drying (seminal study: ~2x faster).
VerifiedOne of 2 sources behind this claim · see the other
The record
Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig.
WINTER GD · 1962 · Nature 193:293-4
PMID 14007593DOI
VerifiedOne of 2 sources behind this claim · see the other
The record
Comparison of skin graft donor site management using oxidised regenerated cellulose (ORC)/collagen/silver-ORC with absorptive silicone adhesive border and transparent film dressing vs semi-occlusive dressings.
Chowdhry SA · 2023 · International wound journal 20:1112-1117
PMID 36151766PMC10030937DOI
C9-2
Silicone gel/sheeting is the internationally recommended first-line OTC scar-prevention intervention (occlusion + hydration normalizes scar-cell overactivity); underlying RCT evidence for scar therapies generally carries some uncertainty per Cochrane, but silicone remains first-line consensus.
VerifiedOne source behind this claim
The record
The Use of Silicone Adhesives for Scar Reduction.
Bleasdale B, Finnegan S, Murray K, Kelly S, Percival SL · 2015 · Advances in wound care 4:422-430
PMID 26155385PMC4486716DOI
C9-3
Neomycin is among the most common contact allergens identified in patch testing (pooled prevalence 3.2% adults, 6.4% North America); ACDS Allergen of the Year 2010.
VerifiedOne source behind this claim
The record
Prevalence of Contact Allergy to Neomycin in Dermatitis Patients: A Systematic Review and Meta-Analysis.
Jensen MB, Isufi D, Larsen CK, Schwensen JFB, Alinaghi F, Johansen JD · 2025 · Contact dermatitis 93:1-15
PMID 40107276PMC12134448DOI
C9-4
Topical vitamin E does not improve scar appearance (no effect or worsened in 90% of a split-scar trial) and causes contact dermatitis in ~33% of users.
VerifiedOne of 2 sources behind this claim · see the other
The record
The effects of topical vitamin E on the cosmetic appearance of scars.
Baumann LS, Spencer J · 1999 · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 25:311-5
PMID 10417589DOI
VerifiedOne of 2 sources behind this claim · see the other
The record
The Role of Topical Vitamin E in Scar Management: A Systematic Review.
Tanaydin V, Conings J, Malyar M, van der Hulst R, van der Lei B · 2016 · Aesthetic surgery journal 36:959-65
PMID 26977069DOI
C9-5
Keloid formation is significantly more prevalent in Fitzpatrick IV-VI populations.
VerifiedOne of 2 sources behind this claim · see the other
The record
Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.
Greene CA, Hampton G, Jaworski J, Shuey MM, Khan A, Luo Y, Jarvik GP, Namjou-Khales B, Edwards TL, Velez Edwards DR, Hellwege JN · 2025 · Nature communications 16:7770
PMID 40835838PMC12368108DOI
VerifiedOne of 2 sources behind this claim · see the other
The record
Keloid disease: Review with clinical atlas. Part I: Definitions, history, epidemiology, clinics and diagnosis.
Delaleu J, Charvet E, Petit A · 2023 · Annales de dermatologie et de venereologie 150:3-15
PMID 36494213DOI
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