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9 claims · 11 studies · 1 reference.

C11-1
Chronic friction induces hyperpigmentation (frictional melanosis).
VerifiedOne of 2 sources behind this claim · see the other
The record
Current understanding of frictional dermatoses: A review.
Arora G, Khandpur S, Bansal A, Shetty B, Aggarwal S, Saha S, Sachdeva S, Gupta M, Sharma A, Monalisa K, Bhandari M, Bagrodia A · 2023 · Indian journal of dermatology, venereology and leprology 89:170-188
VerifiedOne of 2 sources behind this claim · see the other
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Frictional melanosis: A pediatric case series
David Holzer, Karolyn Wanat, Leah Lalor · 2021 · Pediatric Dermatology 38:1345-1346
C11-2
Occlusion and hydration increase how deeply/quickly topical actives penetrate skin.
VerifiedOne of 2 sources behind this claim · see the other
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The Effect of Sequential Topical Application of Dermatologic Medications on Absorption: Clinical Considerations.
Burstein SE, Maibach HI · 2026 · Skin pharmacology and physiology 39:84-98
VerifiedOne of 2 sources behind this claim · see the other
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Methodology to measure the transient effect of occlusion on skin penetration and stratum corneum hydration in vivo
K. S. RYATT, M. MOBAYEN, J. M. STEVENSON, H. I. MAIBACH, R. H. GUY · 1988 · British Journal of Dermatology 119:307-312
C11-4
Pregnancy-related hyperpigmentation is common and usually eases postpartum.
VerifiedOne source behind this claim
The record
Physiological Skin Changes During Pregnancy
KELLY H. TYLER · 2015 · Clinical Obstetrics & Gynecology 58:119-124
C11-5
PIH is often chronic; improves only partially and slowly.
VerifiedOne of 2 sources behind this claim · see the other
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Treatment of Post-Inflammatory Hyperpigmentation in Skin of Colour: A Systematic Review
Kristie Mar, Bushra Khalid, Mahan Maazi, Rayan Ahmed, Ou Jia (Emilie) Wang, Touraj Khosravi-Hafshejani · 2024 · Journal of Cutaneous Medicine and Surgery 28:473-480
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Management of hyperpigmentation: Current treatments and emerging therapies
Avni Nautiyal, Sarika Wairkar · 2021 · Pigment Cell & Melanoma Research 34:1000-1014
C20-3
Hypo-oestrogenism lowers water retention and impairs barrier function, raising irritant-dermatitis risk.
VerifiedOne source behind this claim
The record
Menopause, skin and common dermatosis. Part 3: genital disorders.
Esra Musbahi, Erin Kamp, Mariha Ashraf, Claudia DeGiovanni · 2022 · Clinical and experimental dermatology 47:2123-2129
C20-4
General management of vulvar dermatoses is gentle cleansing, avoidance of irritants, optimized skincare, patch testing where contact allergy is suspected.
VerifiedOne source behind this claim
The record
Update vulval dermatology - diagnostics and therapy.
Christine Brägelmann, Linn Wölber, Laura Susok, Waltraud Anemüller, Wiebke Prüßmann, Irina Ivanova, Dennis Niebel · 2025 · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 23:65-86
C20-5
Lichen simplex chronicus produces hyperpigmented lichenified plaques from rubbing; PIH/hypopigmentation varies with natural skin color.
VerifiedOne source behind this claim
The record
Vulvar Dermatoses: A Review and Update.
Cassandra Simonetta, Erin K Burns, Mary A Guo · 2015 · Missouri medicine 112:301-7
C20-6
Few studies focus on vulvar disease in skin of color; lichen sclerosus, vitiligo, and inflammatory vulvitis are frequently misdiagnosed as one another; mean delay to LS diagnosis 16.43 months.
VerifiedOne source behind this claim
The record
Insights from a joint pediatric dermatology‐gynecology vulvar clinic: A retrospective study
Nikita Menta, Dillon Nussbaum, Aneka Khilnani, Tazim Dowlut‐McElroy, Kaiane A. Habeshian · 2024 · Pediatric Dermatology 41:41-45
C20-7
Lichen sclerosus is often misdiagnosed as vitiligo on darker skin due to hypopigmentation contrast; scarring and thickening are the distinguishing signs vitiligo does not produce.
Patient organizationVerifiedSource record for this claim
The record
Lichen Sclerosus Support Network
Lichen Sclerosus Support Network